추천 제품
![Adenosine 5′-[γ-thio]triphosphate tetralithium salt ≥75% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/319/398/e29221c2-3649-455b-bd33-583bb017ec7d/640/e29221c2-3649-455b-bd33-583bb017ec7d.png)
생물학적 소스
Streptomyces platensis
분석
≥90% (HPLC)
양식
solid
색상
white to beige
solubility
DMSO: 1 mg/mL, clear, colorless
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
동작 모드
enzyme | inhibits
저장 온도
−20°C
SMILES string
O=C1C=C[C@]2(C[H])[C@H]3CC[C@@](O3)([H])C2C1CCC(CNC4=C(O)C=CC(C(O)=O)=C4O)=O
InChI
1S/C22H25NO7/c1-22-9-8-14(25)12(18(22)16-6-7-17(22)30-16)3-2-11(24)10-23-19-15(26)5-4-13(20(19)27)21(28)29/h4-5,8-9,12,16-18,23,26-27H,2-3,6-7,10H2,1H3,(H,28,29)/t12?,16-,17+,18?,22+/m0/s1
InChI key
IGBNLKVUOHQLTO-MBQNLBDGSA-N
애플리케이션
Platensimycin (PTM) is a broad-spectrum antibiotic produced by LStreptomyces platensis. Platensimycin is used to inhibit lipid biosynthesis. It is used in diabetes research and to study the potential treatment of metabolic disorders[1].
생화학적/생리학적 작용
Demonstrates no cross-resistance to other antibiotic-resistant bacteria, including MRSA (methicillin-resistant Staphylococcus aureus).
Mode of action: Selectively inhibits lipid biosynthesis by targeting FabF/B within the fatty acid synthesis pathway.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of action: Selectively inhibits lipid biosynthesis by targeting FabF/B within the fatty acid synthesis pathway.
Antimicrobial spectrum: Gram-positive bacteria.
Platensimycin selectively inhibits the elongation-condensing enzymes FabF/B of the fatty acid biosynthesis pathway in bacteria. PTM is a potent and highly selective inhibitor of mammalian fatty acid synthase. Platensimycin specifically inhibits fatty acid synthesis but not sterol synthesis in rat primary hepatocytes[1]. It is thought that the thiol group of FabF Cys163 may be activated through the dipole moment of helix N-α-3 which lowers the pKa[2]. It does not demonstrate cross-resistance to other antibiotic-resistant bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). It is active against Gram-positive bacteria.
Selectively inhibits lipid biosynthesis by targeting FabF/B within the fatty acid synthesis pathway.
기타 정보
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Makoto Hibi et al.
Communications biology, 4(1), 16-16 (2021-01-06)
The high-valent iron-oxo species formed in the non-heme diiron enzymes have high oxidative reactivity and catalyze difficult chemical reactions. Although the hydroxylation of inert methyl groups is an industrially promising reaction, utilizing non-heme diiron enzymes as such a biocatalyst has
Yuta Tsunematsu et al.
Journal of the American Chemical Society, 143(1), 206-213 (2020-12-23)
Epidithiodiketopiperazines (ETPs) are a class of ecologically and medicinally important cyclodipeptides bearing a reactive transannular disulfide bridge. Aspirochlorine, an antifungal and toxic ETP isolated from Aspergillus oryzae used in sake brewing, deviates from the common ETP scaffold owing to its
Allen C Price et al.
Journal of bacteriology, 185(14), 4136-4143 (2003-07-03)
The beta-ketoacyl-acyl carrier protein synthases are members of the thiolase superfamily and are key regulators of bacterial fatty acid synthesis. As essential components of the bacterial lipid metabolic pathway, they are an attractive target for antibacterial drug discovery. We have
Szu-Yi Hsu et al.
ACS synthetic biology, 8(10), 2397-2403 (2019-09-06)
Serofendic acid is a natural neuroprotective molecule found in fetal calf serum. It is able to protect neurons against mechanisms of cell death associated with neurodegenerative disease. Because only trace quantities are present in fetal calf serum and complete chemical
Molly J McBride et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(4) (2021-01-21)
In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates N δ and N ω' of N ω-methyl-l-arginine before oxidatively rearranging the triply modified guanidine to the N-methyl-N-nitrosourea pharmacophore. A previously published structure visualized the monoiron
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
