H9415
5HPP-33
≥98% (HPLC), solid
동의어(들):
2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione, 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩165,547
25 MG
₩597,937
모든 사진(1)
크기 선택
보기 변경
5 MG
₩165,547
25 MG
₩597,937
About This Item
실험식(Hill 표기법):
C20H21NO3
CAS Number:
Molecular Weight:
323.39
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
solid
색상
white to off-white
solubility
DMSO: >20 mg/mL
저장 온도
2-8°C
SMILES string
CC(C)c1cccc(C(C)C)c1N2C(=O)c3ccc(O)cc3C2=O
InChI
1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3
InChI key
LAKWINYVWJPHQW-UHFFFAOYSA-N
생화학적/생리학적 작용
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Nicole Kleinstreuer et al.
PLoS computational biology, 9(4), e1002996-e1002996 (2013-04-18)
Vascular development is a complex process regulated by dynamic biological networks that vary in topology and state across different tissues and developmental stages. Signals regulating de novo blood vessel formation (vasculogenesis) and remodeling (angiogenesis) come from a variety of biological
Takahiro Hamoya et al.
Journal of clinical biochemistry and nutrition, 60(3), 199-207 (2017-06-07)
It is important to establish effective methods for preventing colorectal cancer because the number of colorectal cancer deaths is increasing. Erythromycin one of the macrolide antibiotics, has been shown to exert pleiotropic effects, such as anti-inflammatory and anti-oxidative effects, on
Nicole C Kleinstreuer et al.
Environmental health perspectives, 119(11), 1596-1603 (2011-07-27)
Understanding health risks to embryonic development from exposure to environmental chemicals is a significant challenge given the diverse chemical landscape and paucity of data for most of these compounds. High-throughput screening (HTS) in the U.S. Environmental Protection Agency (EPA) ToxCast™
Robert G Ellis-Hutchings et al.
Reproductive toxicology (Elmsford, N.Y.), 70, 82-96 (2017-05-22)
Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical disruption of cardiovascular development induces broad prenatal defects. High throughput screening (HTS) assays aid AOP development although linking in vitro data to in vivo apical endpoints remains challenging.
CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response.
Maria Ivshina et al.
Molecular and cellular biology, 35(3), 610-618 (2014-12-03)
The cytoplasmic-element-binding (CPEB) protein is a sequence-specific RNA-binding protein that regulates cytoplasmic polyadenylation-induced translation. In mouse embryo fibroblasts (MEFs) lacking CPEB, many mRNAs encoding proteins involved in inflammation are misregulated. Correlated with this aberrant translation in MEFs, a macrophage cell
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