O5761

Osteocalcin fragment 1-49 Human

≥94% (HPLC), solid

• 실험식(Hill 표기법): C₂₆₉H₃₈₁N₆₇O₈₂S₂
• CAS Number: 136461-80-8
• Molecular Weight: 5929.43
• MDL number: MFCD03457847
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 분석: ≥94% (HPLC)
• 양식: solid
• UniProt 수납 번호: P02818
• 저장 온도: −20°C
• 유전자 정보: human ... BGLAP(632)

설명

Amino Acid Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]

일반 설명

Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.[1][2][3]

Calcium-binding protein found in dentin and possibly other mineralized tissues.

애플리케이션

Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.[4][5]

생화학적/생리학적 작용

Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.[1][6][7]

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable