O2756

Oxytetracycline hemicalcium salt

• Linear Formula: C₂₂H₂₄N₂O₉ · 1/2Ca
• CAS Number: 15251-48-6
• Molecular Weight: 480.47
• EC Number: 239-293-7
• MDL number: MFCD00151362
• UNSPSC 코드: 51101500
• PubChem Substance ID: 24897968

속성

• solubility: formic acid: 50 mg/mL, very slightly hazy, orange to very deep orange
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)C3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1[O-])C(=O)c4c(O)cccc4[C@@]3(C)O.CN(C)[C@H]5[C@@H]6[C@@H](O)C7C(=C(O)[C@]6(O)C(=O)C(C(N)=O)=C5[O-])C(=O)c8c(O)cccc8[C@@]7(C)O
• InChI: 1S/2C22H24N2O9.Ca/c2*1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h2*4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);/q;;+2/p-2/t2*12?,13-,14+,17+,21-,22+;/m11./s1
• InChI key: KIPLYOUQVMMOHB-JOFVZRTQSA-L

설명

일반 설명

Chemical structure: tetracycline

애플리케이션

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes.

생화학적/생리학적 작용

Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS08,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H361d,H411
• 예방조치 성명서: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)