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Merck
모든 사진(1)

주요 문서

N3762

Sigma-Aldrich

Neuromedin B

≥90% (HPLC)

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About This Item

실험식(Hill 표기법):
C52H73N15O12S
CAS Number:
Molecular Weight:
1132.29
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

분석

≥90% (HPLC)

양식

powder

저장 온도

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2cnc[nH]2)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CN)C(C)O)C(N)=O

InChI

1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)

InChI key

YPFNACALNKVZNK-UHFFFAOYSA-N

Amino Acid Sequence

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2

일반 설명

Neuromedin B (NMB) belongs to the bombesin (BN)-like peptide family in mammals. It is located in the gastrointestinal tract and central nervous system.

애플리케이션

Neuromedin B (NMB) has been used as a bombesin (BN)-like peptide:
  • for injection in mice to understand energy expenditure and oxygen consumption and CO2 production
  • to study its effects on the thyrotropin (TSH) and prolactin (PRL) release in vitro
  • to analyze its effects on angiogenesis through the activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in endothelial cells

생화학적/생리학적 작용

Neuromedin B (NMB) exhibits its effects by binding to the cell surface receptors. It facilitates its action on several contractile organs including, the stomach, intestine, esophagus, gall bladder, urinary bladder, and uterus. It also plays a role in food intake, hypothermia, and thermoregulation. NMB is involved in exocrine and endocrine secretion of gastrin, insulin, cholecystokinin, enteroglucagon, and gastric inhibitory peptide. It also acts as an autocrine growth factor in non-small cell lung cancer.

특징 및 장점

This compound is featured on the Bombesin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Rachel Moraes Moreira et al.
Life sciences, 72(8), 917-923 (2002-12-21)
Neuromedin B(NB), a bombesin-like peptide, has been shown to inhibit thyrotropin (TSH) release in pituitary explants of male rats and to stimulate Prolactin (PRL) release in male pituitary cell cultures. We investigated the effect of estrogen status of female rats
Ilja Ignatjev et al.
The journal of physical chemistry. B, 115(35), 10525-10536 (2011-08-05)
Surface-enhanced Raman scattering (SERS), electrochemistry, and generalized two-dimensional correlation analysis (G2DCA) methods were used to define neuromedin B (NMB) ordered superstructures on Ag, Au, and Cu electrode surfaces at different applied electrode potentials in an aqueous solution at physiological pH.
Samar Abdulkhalek et al.
Cellular signalling, 24(11), 2035-2042 (2012-07-05)
The mechanism(s) behind GPCR transactivation of TLR receptors independent of TLR ligands is unknown. Here, GPCR agonists bombesin, bradykinin, lysophosphatidic acid (LPA), cholesterol, angiotensin-1 and -2, but not thrombin induce Neu1 activity in live macrophage cell lines and primary bone
Z Merali et al.
Behavioural brain research, 198(1), 105-112 (2008-11-19)
Repeated exposure to stressors was reported to increase the expression of arginine-vasopressin (AVP), especially in corticotropin-releasing hormone (CRH) neurons co-expressing AVP, within the hypothalamus. This may increase the potential for subsequent stressor-elicited enhancement of hypothalamic-pituitary-adrenal (HPA) functioning as these peptides
L E Heasley
Oncogene, 20(13), 1563-1569 (2001-04-21)
Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. In addition to polypeptide growth factors such as EGF family members which signal through receptor tyrosine kinases, accumulating evidence supports the autocrine

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