N3398

S-Nitroso-N-acetyl-DL-penicillamine

≥97%, powder

• 동의어(들): N-Acetyl-3-(nitrosothio)-DL-valine, S-Nitroso-N-acetylpenicillamine, SNAP
• 실험식(Hill 표기법): C₇H₁₂N₂O₄S
• CAS Number: 67776-06-1
• Molecular Weight: 220.25
• MDL number: MFCD00272624
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24278584
• NACRES: NA.32

속성

• Quality Level: 300
• 분석: ≥97%
• 형태: powder
• 색상: faint green to very dark green
• solubility: H₂O: ≥2 mg/mL; DMSO: ≥20 mg/mL, clear (faint green to very dark green)
• 저장 온도: −20°C
• SMILES string: CC(=O)NC(C(O)=O)C(C)(C)SN=O
• InChI: 1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)
• InChI key: ZIIQCSMRQKCOCT-UHFFFAOYSA-N

설명

애플리케이션

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has been used:

• as a positive control in nitrite generation assay.
• to block the activity of endogenous transglutaminase (TG2).
• in proliferation assays to generate nitric oxide (NO) in cell cultures.

생화학적/생리학적 작용

NO donor; vasodilator, smooth muscle relaxant, lymphocyte activator. Activates soluble guanylyl cyclase.

SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves