N1019

(−)-Nicotine hemisulfate salt

≥95% (TLC), ~35 % (w/v) in H₂O (based on free base)

• 동의어(들): (−)-1-Methyl-2-(3-pyridyl)pyrrolidine
• Linear Formula: (C₁₀H₁₄N₂)₂ · H₂SO₄
• CAS Number: 65-30-5
• Molecular Weight: 422.54
• MDL number: MFCD00148918
• UNSPSC 코드: 12352210
• PubChem Substance ID: 24897454
• NACRES: NA.77

속성

• 분석: ≥95% (TLC)
• 형태: liquid
• 농도: ~35 % (w/v) in H₂O (based on free base)
• 색상: dark brown
• SMILES string: OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
• InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
• InChI key: IECQULMJVNSKDB-RCWTXCDDSA-N
• 유전자 정보: human ... CHRNA4(1137) , CHRNB2(1141)

설명

일반 설명

Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.

애플리케이션

(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.

생화학적/생리학적 작용

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

품질

Mixture of nicotine base and nicotine sulfate.

주의사항

Shelf-life of the solution as supplied is at least six years when stored at room temperature.

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H310 + H330,H411
• 예방조치 성명서: P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3