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추천 제품
생물학적 소스
mouse (CD-1)
Quality Level
양식
liquid
포장
vial of ~10 mg
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
mouse ... Mgst1(56615)
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일반 설명
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]
애플리케이션
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents[2] and tunicamycin.[3]
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.[4]
생화학적/생리학적 작용
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[5] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.[6]
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
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Metabolism of small antimicrobial ?(2,2)-amino acid derivatives by murine liver microsomes.
Hansen T
Eur. J. Drug Metab. Pharmacokinet., 37(3), 191-201 (2012)
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European journal of medicinal chemistry, 127, 357-368 (2017-01-12)
A series of spirocyclic compounds inspired by Eli Lilly's phase 1 antidiabetic FFA1 receptor agonist LY2881835 was designed to include polar aromatic periphery groups and explore a possibility of building additional contacts with the target near the agonist binding site.
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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