M9020

Mecamylamine hydrochloride

≥98% (TLC), powder, nAChR antagonist

• 동의어(들): 2-(Methylamino)isocamphane hydrochloride, Inversine, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
• 실험식(Hill 표기법): C₁₁H₂₁N · HCl
• CAS Number: 826-39-1
• Molecular Weight: 203.75
• EC Number: 212-555-8
• MDL number: MFCD00151462
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24277851
• NACRES: NA.77

속성

• product name: Mecamylamine hydrochloride,
• 형태: powder
• Quality Level: 200
• solubility: ethanol: 122 mg/mL; H₂O: 47 mg/mL; isopropanol: 476 mg/mL; glycerol: 95 mg/mL
• 주관자: AstraZeneca
• SMILES string: Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
• InChI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
• InChI key: PKVZBNCYEICAQP-CIISUUNXSA-N
• 유전자 정보: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

설명

애플리케이션

Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.

생화학적/생리학적 작용

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

주의사항

Solutions are stable to autoclaving.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves