M8816

Microsomes from Liver, Pooled

from Monkey(Cynomolgus spp.), male

• 동의어(들): lab equipment accessory
• UNSPSC 코드: 12161501
• NACRES: NB.35

속성

• 생물학적 소스: Monkey (Cynomolgus spp.)
• 양식: liquid
• 특이 활성도: ≥5000 units/mg protein
• 포장: vial of ~10 mg
• 배송 상태: dry ice
• 저장 온도: −70°C

설명

애플리케이션

Microsomes from Liver, Pooled has been used to measure the in vitro stabilities of the prodrugs.[1] It has also been used in microsomal incubation to generate BTX-3 metabolites to serve as references for liquid chromatography with tandem mass spectrometry (LC-MS/MS) analyses of urine.[2]

생화학적/생리학적 작용

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomal cytochrome P450 proteins can catalyze the transfer of a single oxygen atom to endogenous and exogenous compounds, like steroids and phenobarbital, meant for excretion and detoxification.[3]

Source of drug metabolizing enzymes, including cytochrome P-450.

단위 정의

One unit will produce 1.0 picomole of 6 beta-hydroxytestosterone per minute at pH 7.4 at 37 deg C.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable