M6891

Mithramycin A from Streptomyces plicatus

≥90% (HPLC)

• 동의어(들): Aureolic acid, Plicamycin
• 실험식(Hill 표기법): C₅₂H₇₆O₂₄
• CAS Number: 18378-89-7
• Molecular Weight: 1085.15
• Beilstein: 5236667
• MDL number: MFCD00135618
• UNSPSC 코드: 12161501
• PubChem Substance ID: 24897127
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥90% (HPLC)
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: DNA synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: [H][C@]1(Cc2cc3cc(O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@@H](O)[C@@H](C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1O[C@H]6C[C@@H](O[C@H]7C[C@@H](O[C@H]8C[C@](C)(O)[C@H](O)[C@@H](C)O8)[C@H](O)[C@@H](C)O7)[C@H](O)[C@@H](C)O6)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O
• InChI: 1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43+,44-,45-,49+,50+,51-,52+/m1/s1
• InChI key: CFCUWKMKBJTWLW-BGLFSJPPSA-N

설명

일반 설명

Chemical structure: aureolic acid

생화학적/생리학적 작용

Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes.

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves