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Merck
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C8124

Sigma-Aldrich

CH-223191

≥98% (HPLC), powder, AhR antagonist

동의어(들):

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phen yl-1H-pyrazole-5-carboxamide, 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide

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크기 선택

5 MG
₩231,522
25 MG
₩922,838

₩231,522

출고 가능일2025년 4월 09일세부사항

벌크 견적 요청
모든 사진(1)

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보기 변경
5 MG
₩231,522
25 MG
₩922,838

About This Item

실험식(Hill 표기법):
C19H19N5O
CAS Number:
301326-22-7
Molecular Weight:
333.39
MDL number:
MFCD00377884
UNSPSC 코드:
12352200
PubChem Substance ID:
329775161
NACRES:
NA.77

₩231,522

출고 가능일2025년 4월 09일세부사항

벌크 견적 요청

제품명

CH-223191,

분석

≥98% (HPLC)

Quality Level

100

양식

powder

색상

orange-brown

solubility

DMSO: ≥20 mg/mL

저장 온도

2-8°C

SMILES string

Cc1cc(ccc1NC(=O)c2ccnn2C)\N=N\c3ccccc3C

InChI

1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+

InChI key

LKTNEXPODAWWFM-GHVJWSGMSA-N

애플리케이션

CH-223191 has been used as aryl hydrocarbon receptor (AHR) antagonist in HepaRG cells,[1] TH17-IL-10+ cells[2] and organoids.[3]

생화학적/생리학적 작용

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist.
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It inhibited TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibited TCDD-induced luciferase activity with an IC50 of 30nM. Unlike some other AhR antagonists which display agonist activity at high concentrations, CH-223191 did not stimulate AhR-dependent transcription even at 100 micromolar. It is also specific for AhR, displaying no affinity for the estrogen receptor, as some other antagonists do.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000388488
0000388490
0000157504
0000251839
0000322704

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH 17 cells
Aschenbrenner D, et al.
Nature Immunology, 19(10), 1126-1126 (2018)
Lei Dong et al.
Scientific reports, 6, 36598-36598 (2016-11-04)
Understanding of T helper 17 lineage (T
Michela Zago et al.
PloS one, 8(9), e74953-e74953 (2013-10-03)
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-made environmental toxicants, has emerged as an endogenous regulator of cyclooxygenase-2 (Cox-2) by a mechanism that is poorly understood. In this study, we first used AhR-deficient (AhR(-/-) )
Qin Wang et al.
Environmental health perspectives, 121(11-12), 1334-1343 (2013-09-24)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of xenobiotic detoxification genes and is a critical mediator of gene-environment interactions. Many AHR target genes identified by genome-wide gene expression profiling have morphogenetic functions, suggesting
Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells
Attignon E, et al.
Toxicology in vitro, 45, 309-317 (2017)
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