추천 제품
재조합
expressed in E. coli
Quality Level
형태
buffered aqueous solution
특이 활성도
5,000 units/mg protein
분자량
20 kDa
농도
~0.1 mg/mL
UniProt 수납 번호
관련 질환(들)
cancer
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... MMP7(4316)
일반 설명
Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.
애플리케이션
Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.
생화학적/생리학적 작용
Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.
물리적 형태
Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl
분석 메모
One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 °C.
Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Matrilysin.
Wilson, C.L. et al.
Matrix Metalloproteinases, 149-149 (1998)
Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions.
Cossins JA
Acta Neuropathologica, 94(6), 590-598 (1997)
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.
Grindel BJ, et.al.
Matrix Biology, 36, 64-76 (2014)
Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases.
Zeng ZS
Clinical Cancer Research, 8(1), 144-148 (2002)
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Knox JD
Cytogenetics and Cell Genetics, 72(2-3), 179-182 (1996)
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