추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 120 kDa
종 반응성
rat
기술
immunoprecipitation (IP): 5-10 μg using a rat brain extract (S1 fraction).
microarray: suitable
western blot: 0.25-0.5 μg/mL using rat brain extract (S1 fraction)
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... APBA2(321)
mouse ... Apba2(11784)
rat ... Apba2(83610)
관련 카테고리
일반 설명
Munc-18-1 interacting protein 2 (Mint2), also called X11L, shares 50% homology with Mint1 and both are expressed exclusively in brain and bind Munc-18-1 with high affinity. It has N-terminal Munc-18-1-interacting domain (MID), a middle phosphotyrosine-binding (PTB) domain, and two C-terminal PDZ domain. It belongs to mammalian LIN-10 protein family. Mint 2 is present in neurons.
면역원
synthetic peptide corresponding to amino acids 1-18, located at the N-terminus of rat mint2, conjugated to KLH. This sequence is highly conserved (single amino acid substitution) in mouse mint2 and shows limited homology (66% identity) to human mint2. It does not share homology with the mint1 and mint3 isoforms.
애플리케이션
Anti-Mint2 antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunostaining
생화학적/생리학적 작용
Munc-18-1 interacting protein 2 (Mint2) participates in vesicle exocytosis. Mint 2 interacts with amyloid-β precursor protein (APP) and presenilins. It favors phosphorylation of β-amyloid precursor protein family members APP and Amyloid-like protein 2 (APLP2) in response to cellular stress, by facilitating c-Jun N-terminal kinase mediated phosphorylation.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid $\beta$ generation
Sullivan S, et al.
The Journal of Biological Chemistry, 289(22), 15374-15383 (2014)
Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms
Biederer T, et al.
The Journal of Neuroscience, 22(17), 7340-7351 (2002)
Intracellular amyloid precursor protein sorting and amyloid-$\beta$ secretion are regulated by Src-mediated phosphorylation of Mint2
Chaufty J, et al.
The Journal of Neuroscience, 32(28), 9613-9625 (2012)
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein
Taru H and Suzuki T
Test, 279(20), 21628-21636 (2004)
Amy Y Lin et al.
Scientific reports, 9(1), 6024-6024 (2019-04-17)
MINT2/APBA2 is a synaptic adaptor protein involved in excitatory synaptic transmission. Several nonsynonymous coding variants in MINT2 have been identified in autism spectrum disorders (ASDs); however, these rare variants have not been examined functionally and the pathogenic mechanisms are unknown.
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