모든 사진(1)
About This Item
Linear Formula:
C19H13N3O2
CAS Number:
Molecular Weight:
315.33
UNSPSC 코드:
12352202
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic (organic)
분석
≥98%
형태
solid
solubility
chloroform/methanol (4:1): 4 mg/mL, clear to slightly hazy, colorless to yellow
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... TOP1(7150)
일반 설명
Luotonin E is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and B, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.
생화학적/생리학적 작용
Luotonin E exhibited strong cytotoxic effects specifically on human leukemia P-388 cells.
재구성
Solubility is tested at 4 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Two New Quinazoline-Quinoline Alkaloids from Peganum nigellastrum
Ma, Z.-Z., et al.
Heterocycles, 51, 1883-1889 (1999)
Jing Lu Liang et al.
Molecules (Basel, Switzerland), 16(6), 4861-4883 (2011-06-17)
Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All
Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.
Zhongze Ma et al.
Bioorganic & medicinal chemistry letters, 14(5), 1193-1196 (2004-02-26)
Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F
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