L2023

Leupeptin trifluoroacetate salt

powder, ≥90% (HPLC)

• 동의어(들): Acetyl-Leu-Leu-Arg-al trifluoroacetate salt
• 실험식(Hill 표기법): C₂₀H₃₈N₆O₄ · xC₂HF₃O₂
• CAS Number: 147385-61-3
• Molecular Weight: 426.55 (free base basis)
• MDL number: MFCD00133458
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329817397
• NACRES: NA.77

속성

• 제품명: Leupeptin trifluoroacetate salt, ≥90% (HPLC), microbial
• 생물학적 소스: microbial
• Quality Level: 200
• 분석: ≥90% (HPLC)
• 양식: powder
• solubility: H₂O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)
• 저장 온도: −20°C
• SMILES string: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1
• InChI key: WUHGBZVQELGOMH-FRKSIBALSA-N

설명

생화학적/생리학적 작용

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

분석 메모

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)