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Merck
모든 사진(1)

주요 문서

L137

Sigma-Aldrich

L-733,060 hydrochloride

solid, ≥98% (HPLC)

동의어(들):

(2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride

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About This Item

실험식(Hill 표기법):
C20H19F6NO · HCl
CAS Number:
Molecular Weight:
439.82
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:

분석

≥98% (HPLC)

양식

solid

색상

white

solubility

DMSO: >10 mg/mL
H2O: insoluble

저장 온도

2-8°C

SMILES string

Cl[H].FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c3ccccc3)cc(c1)C(F)(F)F

유전자 정보

human ... TACR1(6869)

생화학적/생리학적 작용

Non-peptide NK1 tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse. Micromolar concentrations of L-733,060 inhibit the growth of human gastric and colon adenocarcinomas.in a dose-dependent manner, eventually leading to apoptosis in both cell lines.

법적 정보

Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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시험 성적서(COA)

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문서 라이브러리 방문

P Kiatpapan et al.
Journal of bioscience and bioengineering, 92(5), 459-465 (2005-10-20)
To develop systems for the expression of heterologous genes in probiotic strains of Lactobacillus and Propionibacterium, we used Lactobacillus plantarum and Propionibacterium freudenreichii and a modified gene encoding cholesterol oxidase (choA) from Streptomyces sp. to generate working models. The acetyl
Jitka Myskova et al.
Journal of medical entomology, 45(1), 133-138 (2008-02-21)
Quantification of Leishmania parasites in the sand fly digestive tract is important for evaluation of vector competence. We compared quantitative polymerase chain reaction (Q-PCR) with two "traditional" methods, estimation in situ and direct counting with the aid of a hemocytometer
Jong-Hyun Kim et al.
Journal of bioscience and bioengineering, 107(2), 124-129 (2009-02-17)
A gene (apuA) encoding amylopullulanase from a starch-hydrolyzing lactic acid bacterium, Lactobacillus plantarum L137, which had been isolated from traditional fermented food made from fish and rice in the Philippines, was found to contain two unique amino acid repeating units
Y Kaneko et al.
Journal of bioscience and bioengineering, 89(1), 62-67 (2005-10-20)
Lactobacillus plantarum NC13, a strain derived from the L. plantarum strain L137 isolated from a traditional fermented food produced in the Philippines, contains 9 of the 15 plasmids in the parental strain. To construct a shuttle vector between L. plantarum
N M Rupniak et al.
Pain, 67(1), 189-195 (1996-09-01)
Intravenous administration of the NK1 receptor antagonist L-733,060 to gerbils 3 h before intraplantar injection of formalin caused a dose-dependent and complete inhibition of the late, but not early, phase nociceptive response (paw licking). The ID50 for L-733,060 (0.17 mg/kg)

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