J3580

JNJ 17203212

≥98% (HPLC)

• 동의어(들): N¹-(3-Trifluoromethylpyrid-2-yl)-N⁴-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
• 실험식(Hill 표기법): C₁₇H₁₅F₆N₅O
• CAS Number: 821768-06-3
• Molecular Weight: 419.32
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to off-white
• solubility: DMSO: >20 mg/mL
• 주관자: Johnson & Johnson
• 저장 온도: −20°C
• InChI: 1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
• InChI key: JFRYYGVYCWYIDQ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that does not inhibit related TRP channels such as TRPV2, TRPV4, or TRPA1. Listed in BJP with IC50= 65 nM. TRPV1 channels are activated by heat, capsaicin and the endocannabinoid anandamide. Interest in TRPV1 antagonists in the transmission and modulation of pain.

특징 및 장점

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H319
• 예방조치 성명서: P301 + P310 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable