Quality Level
분석
≥98% (HPLC)
양식
solid
solubility
DMSO: ≥28 mg/mL
주관자
Johnson & Johnson
저장 온도
2-8°C
SMILES string
O=C(Nc1ccccc1)N2CCN(CC2)c3nc(ns3)-c4ccccc4
InChI
1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI key
BHBOSTKQCZEAJM-UHFFFAOYSA-N
생화학적/생리학적 작용
JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with >100-fold preferentially selective for FAAH-1 over FAAH-2. FAAH in an integral membrane enzyme within the amidase-signature family. It catalyzes the hydrolysis of several endogenous biologically active lipids and involves in a variety of physiological and pathological processes, including synaptic regulation, regulation of sleep and feeding, locomotor activity, pain and inflammation.
JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor.
특징 및 장점
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Torsten Lowin et al.
Arthritis research & therapy, 17, 321-321 (2015-11-17)
The endocannabinoid system modulates function of immune cells and mesenchymal cells such as fibroblasts, which contribute to cartilage destruction in rheumatoid arthritis (RA). The aim of the study was to determine the influence of N-acylethanolamines anandamide (AEA), palmitoylethanolamine (PEA) and
활성 필터
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