추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
분석
≥98% (SDS-PAGE)
양식
lyophilized powder
효능
≤12 pg/mL ED50
품질
endotoxin tested
분자량
17.3 kDa
포장
pkg of 5 and 25 μg
pkg of 25 μg
기술
cell culture | mammalian: suitable
색상
white to off-white
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IL1B(3553)
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생화학적/생리학적 작용
Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cell lymphocytes, which then proliferate and secrete interleukin-2 (IL-2). IL-1 is released primarily from stimulated macrophages and monocytes, but has also been shown to be released from several other types and is thought to play a key role in inflammatory and immune responses. Other synonyms for IL-1 include: endogenous pyrogen (EP), mitogenic protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFM), B Cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF) The two closely related agents Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) share 62% homology in amino acid sequence and elicit nearly identical biological responses. IL-1α and IL-1β are both approximately 17 kDa with some heterogeneity in the amount of glycosylation.
물리적 형태
Lyophilized from a 0.2 μm filtered buffered solution.
분석 메모
The biological activity is measured by the dose-dependent stimulation of MTS cleavage by murine D10S cells.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
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Tanja Mang et al.
International journal of molecular sciences, 21(2) (2020-01-18)
The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective of this study was to
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Biological & pharmaceutical bulletin, 33(11), 1854-1860 (2010-11-05)
In pancreatic islets, free radical formation produced upon exposure to proinflammatory cytokines mediates β cell destruction, which ultimately leads to type 1 diabetes (T1D). In this study, we examined whether laccase, a family of the blue copper protein, can be
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British journal of pharmacology, 176(24), 4625-4638 (2019-08-14)
Microsomal PGE synthase-1 (mPGES-1), the inducible synthase that catalyses the terminal step in PGE2 biosynthesis, is of high interest as therapeutic target to treat inflammation. Inhibition of mPGES-1 is suggested to be safer than traditional NSAIDs, and recent data demonstrate
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