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Merck
모든 사진(1)

문서

I8529

Sigma-Aldrich

Insulin-like Growth Factor Binding Protein-5 human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

동의어(들):

IGFBP-5

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모든 사진(1)

About This Item

MDL number:
MFCD03457235
UNSPSC 코드:
51111800
NACRES:
NA.32

생물학적 소스

human

Quality Level

100

재조합

expressed in NSO cells

분석

>90% (SDS-PAGE)

형태

lyophilized powder

효능

0.5-1.5 mg per mL ED50

분자량

34 kDa by SDS-PAGE (reducing)
calculated mol wt ~28 kDa

포장

pkg of 25 μg

불순물

endotoxin, tested

UniProt 수납 번호

P24593

저장 온도

−20°C

유전자 정보

human ... IGFBP5(3488)

일반 설명

The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.

생화학적/생리학적 작용

IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

분석 메모

The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

V Hwa et al.
Endocrine reviews, 20(6), 761-787 (1999-12-22)
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other potential IGFBPs was left open. The discovery of
Baxter, R.C.
American Journal of Physiology. Endocrinology and Metabolism, 278 (2000)
Yunyun Su et al.
PloS one, 10(6), e0130546-e0130546 (2015-06-24)
Insulin-like growth factor binding protein (IGFBP)-5 levels are increased in systemic sclerosis (SSc) skin and lung. We previously reported that IGFBP-5 is a pro-fibrotic factor that induces extracellular matrix (ECM) production and deposition. Since IGFBP-5 contains a nuclear localization signal
Maya Ghoussaini et al.
Nature communications, 4, 4999-4999 (2014-09-24)
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes
Mark E Reeves et al.
PloS one, 9(7), e101679-e101679 (2014-07-10)
RASSF1C is a major isoform of the RASSF1 gene, and is emerging as an oncogene. This is in contradistinction to the RASSF1A isoform, which is an established tumor suppressor. We have previously shown that RASSF1C promotes lung cancer cell proliferation

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