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Merck
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I0911

Sigma-Aldrich

IRR (945-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

INSRR

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모든 사진(1)

About This Item

UNSPSC 코드:
12352204
NACRES:
NA.32

재조합

expressed in baculovirus infected Sf9 cells

Quality Level

200

제품 라인

PRECISIO® Kinase

분석

≥70% (SDS-PAGE)

양식

buffered aqueous glycerol solution

특이 활성도

94-128 nmol/min·mg

분자량

~65 kDa

UniProt 수납 번호

P14616

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... INSRR(3645)

일반 설명

IRR (insulin receptor-related receptor) belongs to the insulin receptor (IR) family. It is expressed in neuronal tissues, kidney, pancreas and stomach.[1][2]

생화학적/생리학적 작용

IRR or insulin receptor-related receptor is a tyrosine protein kinase. IRR is an extracellular pH sensor. The IRR mRNA is present in neuroblastomas and may be associated with tumor genesis.[1][2]

물리적 형태

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Igor E Deyev et al.
The Journal of biological chemistry, 288(47), 33884-33893 (2013-10-15)
IRR is a member of the insulin receptor (IR) family that does not have any known agonist of a peptide nature but can be activated by mildly alkaline medium and was thus proposed to function as an extracellular pH sensor.
M W Elmlinger et al.
Regulatory peptides, 84(1-3), 37-42 (1999-10-27)
The insulin receptor-related receptor (IRR) is a member of the insulin receptor family. So far no ligand has yet been discovered for this receptor type (orphan receptor). IRR, insulin receptor (IR), and insulin-like growth factor-I receptor (IGF-I-R) are all tyrosine
B Zhang et al.
The Journal of biological chemistry, 267(26), 18320-18328 (1992-09-15)
In 1989, Shier and Watt identified a gene which was predicted to encode a new member of the insulin receptor (IR) family, and they called it the insulin receptor-related receptor (IRR) (Shier, P., and Watt, V. M. (1989) J. Biol.

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