HPA023644

Anti-STAR antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1

• 동의어(들): Anti-NET29, Anti-STARD1, Anti-TMPIT, Anti-steroidogenic acute regulatory protein
• UNSPSC 코드: 12352203
• 인간 단백질 도해서 번호: HPA023644
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 제품 라인: Prestige Antibodies^® Powered by Atlas Antibodies
• 형태: buffered aqueous glycerol solution
• 종 반응성: human
• 향상된 검증: independent; orthogonal RNAseq; Learn more about Antibody Enhanced Validation
• 기술: immunohistochemistry: 1:200-1:500
• 면역원 서열: QDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELA
• UniProt 수납 번호: P49675
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... STAR(6770)

설명

일반 설명

Steroidogenic acute regulatory protein is located on human chromosome 8p11.2.

면역원

steroidogenic acute regulatory protein recombinant protein epitope signature tag (PrEST)

애플리케이션

Anti-STAR antibody produced in rabbit has been used to detect StAR in Paraffin-embedded adrenal samples using immunohistochemistry.

생화학적/생리학적 작용

Steroidogenic acute regulatory protein (StAR) is essential for the transfer of cholesterol to mitochondria for adrenal and gonadal steroidogenesis. StAR gene analysis can help in the diagnosis of lipoid congenital adrenal hyperplasia (LCAH). It is also identified that activins A,B,AB downregulates StAR and thereby reduces the production of progesterone in human granulosa cells. Hypoxia mediated upregulation of StAR stimulates the synthesis of aldosterone in pulmonary artery endothelial cells which contributes to pulmonary vascular fibrosis. Activation of StAR helps in prevention of atherosclerotic cardiovascular disease.

특징 및 장점

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

결합

Corresponding Antigen APREST76259

물리적 형태

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

법적 정보

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable