HPA000645
Anti-CCNK antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
동의어(들):
Anti-Cyclin-K antibody produced in rabbit
로그인조직 및 계약 가격 보기
크기 선택
100 μL
₩837,477
₩837,477
예상 입고일2025년 6월 17일세부사항
모든 사진(2)
크기 선택
보기 변경
100 μL
₩837,477
About This Item
₩837,477
예상 입고일2025년 6월 17일세부사항
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
클론
polyclonal
제품 라인
Prestige Antibodies® Powered by Atlas Antibodies
양식
buffered aqueous glycerol solution
종 반응성
human
기술
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
면역원 서열
DHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLL
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... CCNK(8812)
면역원
Cyclin-K recombinant protein epitope signature tag (PrEST)
애플리케이션
Anti-CCNK antibody produced in rabbit was used in chromatin immunoprecipitation with RNA polymerase II to study the importance of CCNK in the maintenance of genomic stability.[1]
Anti-CCNK antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting.[1] To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Anti-CCNK antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting.[1] To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
생화학적/생리학적 작용
Cyclin-K is a protein encoded by the CCNK gene in humans. It encodes a 357-amino-acid protein that plays a role in regulating basal transcription through their association with and activation of cyclin-dependent kinases (Cdks) that phosphorylate the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II (RNAP II).[2] It functions as a regulatory subunit of CDK9.[3] Cyclin K is highly expressed in mammalian testes in a developmentally regulated manner and is essential for embryonic stem cell maintenance. It may act as a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.[4] Cyclin K may play a role in regulating the cell cycle or apoptosis after being targeted for transcription by p53.[5]
특징 및 장점
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
결합
Corresponding Antigen APREST70529.
물리적 형태
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
법적 정보
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
M C Edwards et al.
Molecular and cellular biology, 18(7), 4291-4300 (1998-06-25)
The gene coding for human cyclin K was isolated as a CPR (cell-cycle progression restoration) gene by virtue of its ability to impart a Far- phenotype to the budding yeast Saccharomyces cerevisiae and to rescue the lethality of a deletion
Yasmine Even et al.
PloS one, 11(2), e0149184-e0149184 (2016-02-18)
The perinucleolar compartment (PNC) is a subnuclear stucture forming predominantly in cancer cells; its prevalence positively correlates with metastatic capacity. Although several RNA-binding proteins have been characterized in PNC, the molecular function of this compartment remains unclear. Here we demonstrate
A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis.
Xiang X, Deng L, Zhang J, et al.
PLoS ONE, 9(7), e101539-e101539 (2014)
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.
T J Fu et al.
The Journal of biological chemistry, 274(49), 34527-34530 (1999-11-27)
Important progress in the understanding of elongation control by RNA polymerase II (RNAPII) has come from the recent identification of the positive transcription elongation factor b (P-TEFb) and the demonstration that this factor is a protein kinase that phosphorylates the
Dalibor Blazek et al.
Genes & development, 25(20), 2158-2172 (2011-10-21)
Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of transcription. In this study, we identified a 70-kDa Cyclin K (CycK) that binds Cdk12 and Cdk13 to form two different complexes (CycK/Cdk12 or CycK/Cdk13) in human cells. The
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