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Merck
모든 사진(1)

문서

H5902

Sigma-Aldrich

(−)-Huperzine A

동의어(들):

(−)-Selagine, Kimpukan A

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About This Item

실험식(Hill 표기법):
C15H18N2O
CAS Number:
Molecular Weight:
242.32
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:

저장 온도

−20°C

SMILES string

[H][C@@]12CC3=C(C=CC(=O)N3)[C@@](N)(CC(C)=C1)C2=CC

InChI

1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1

InChI key

ZRJBHWIHUMBLCN-YQEJDHNASA-N

유전자 정보

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Acetylcholinesterase inhibitor; active enantiomer.

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


시험 성적서(COA)

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문서 라이브러리 방문

Ling Yang et al.
Journal of Alzheimer's disease : JAD, 31(1), 131-142 (2012-04-26)
A number of recent discoveries indicate that huperzine A, an active herbal medicine employed for the treatment of Alzheimer's disease (AD) in China, can afford neuroprotection on in vitro and in vivo models related to mitochondrial dysfunction. However, it is
Marcus Trapp et al.
The journal of physical chemistry. B, 116(51), 14744-14753 (2012-11-29)
Enzymes are animated by a hierarchy of motions occurring on time scales that span more than 15 orders of magnitude from femtoseconds (10(-15) s) to several minutes. As a consequence, an enzyme is characterized by a large number of conformations
Liu, J.-S., et al.
Canadian Journal of Chemistry, 64, 837-837 (1986)
Paula Lunardi et al.
Life sciences, 92(12), 701-707 (2013-02-13)
The loss of cholinergic function in the central nervous system contributes significantly to the cognitive decline associated with advanced age and dementias. Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive
Hai-Yan Zhang
Acta pharmacologica Sinica, 33(9), 1170-1175 (2012-09-04)
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Accordingly, some new mechanisms of action

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