추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 40 kDa
종 반응성
human, mouse
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using heat retrieved, human intestine tissue
western blot (chemiluminescent): 5-10 μg/mL using mouse brain extract
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ELAVL4(1996)
mouse ... Elavl4(15572)
관련 카테고리
일반 설명
Hu antigen D (HuD) protein is highly conserved and a neuron-specific RNA-binding protein. This protein belongs to the embryonic lethal, abnormal vision, Drosophila-like (ELAVL)/Hu family. The HuD gene is located on the human chromosome at 1p33-p32.3.
특이성
Anti-HuD specifically recognizes human and mouse HuD.
면역원
synthetic peptide corresponding to amino acids 240-255 of human HuD with an N-terminal added cysteine, conjugated to KLH.
애플리케이션
Anti-HuD antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.
생화학적/생리학적 작용
Hu antigen D (HuD) protein binds to the 3′ untranslated region (UTR) of mRNA of genes like N-myc gene and growth-associated protein (GAP43). This binding results in an increase in the half-life of these mRNA. HuD plays a vital role in several regulatory processes, such as the processing of pre-mRNA, mRNA stability and translation. This protein is also involved in neuronal functioning and development. HuD protein also plays a role in neuronal plasticity, which includes, learning and memory, recovery from axonal injury and multiple neurological diseases.
표적 설명
HuD protein binds to the 3′ UTR of mRNA of geneslike N-myc gene and GAP43, and increases the half-life ofthese mRNA.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% inactivated bovine serum albumin.
저장 및 안정성
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
The Chromosomal Aberrations in the Head and Neck Squamous Cell Carcinoma Cell Lines: PCI-1, PCI-13 and PCI-50
Moon Y E, et al.
Korean Journal of Otorhinolaryngology - Head and Neck Surgery, 52(9), 741-750 (2009)
Lucas M Bronicki et al.
RNA (New York, N.Y.), 19(8), 1019-1037 (2013-07-19)
Precise control of messenger RNA (mRNA) processing and abundance are increasingly being recognized as critical for proper spatiotemporal gene expression, particularly in neurons. These regulatory events are governed by a large number of trans-acting factors found in neurons, most notably
Feifei Wang et al.
Anticancer research, 37(8), 4515-4522 (2017-07-26)
The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells. The aim of this study was to investigate the serum HuD concentration in SCLC patients and
Riccardo De Santis et al.
Cell reports, 27(13), 3818-3831 (2019-06-27)
Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs). This analysis identified a number of RNA targets.
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