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추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
양식
liquid
농도
1 mg/mL
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... H1.0(3005)
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일반 설명
Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms.[1] Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.[2]
생화학적/생리학적 작용
The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning.[2] Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects.[3] Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions.[4] Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.[5]
물리적 형태
Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Linker Histone in Diseases
Ye X, et al.
International Journal of Biological Sciences, 13(8), 1008-1018 (2017)
The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Hergeth SP and Schneider R
EMBO Reports, 16(11), 1439-1453 (2015)
H1 histones: current perspectives and challenges
Harshman SW, et al.
Nucleic Acids Research, 41(21), 9593-9609 (2013)
Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development
Hu J, et al.
Cell Death & Disease, 9(7), 765-765 (2018)
Histone H1 null vertebrate cells exhibit altered nucleosome architecture
Hashimoto H, et al.
Nucleic Acids Research, 38(11), 3533-3545 (2010)
활성 필터
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