모든 사진(1)

문서

COO/COA

EHU113561

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human NOTCH2

로그인조직 및 계약 가격 보기

모든 사진(1)

About This Item

UNSPSC 코드:

41105324

NACRES:

NA.51

추천 제품

Slide 1 of 10

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Sigma-Aldrich

EHU092581

MISSION^® esiRNA

Sigma-Aldrich

C3788

Chondroitin sulfate B sodium salt

Sigma-Aldrich

EHU127601

MISSION^® esiRNA

CLS432070

Corning^® CoolSink^®

Sigma-Aldrich

408905

Hexyl acrylate

Sigma-Aldrich

Z370762

Scienceware^® Holdfast^™ graduated cylinders with handle

Z562211

Platinum evaporating dish lid

TMODS2185-0032

Nalgene^® economy wide-mouth bottle

Avanti

860619P

CER6-2′S(d9)

Sigma-Aldrich

EHU131641

MISSION^® esiRNA

설명

제품 라인

MISSION^®

형태

lyophilized powder

esiRNA cDNA 표적 서열

GCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGA

Ensembl | 인체 수납 번호

ENSG00000134250

NCBI 수납 번호

NM_024408

배송 상태

ambient

저장 온도

−20°C

유전자 정보

human ... NOTCH2(100132406) , NOTCH2(388677)

일반 설명

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

법적 정보

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling.

Jie Deng et al.

Journal of experimental & clinical cancer research : CR, 38(1), 2-2 (2019-01-05)

Glioblastomas multiforme (GBM) is the most devastating primary intracranial malignancy lacking effective clinical treatments. Notch2 has been established to be a prognostic marker and probably involved in GBM malignant progression. N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), has been

miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC.

Xiaoyuan Wang et al.

Stem cell research & therapy, 9(1), 327-327 (2018-11-25)

Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA disorders are involved in the pathogenesis of human diseases, such

Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.

Mercedes Tomé et al.

Stem cell research, 35, 101390-101390 (2019-02-15)

Notch signalling regulates neural stem cell (NSC) proliferation, differentiation and survival for the correct development and functioning of the central nervous system. Overactive Notch2 signalling has been associated with poor prognosis of aggressive brain tumours, such as glioblastoma multiforme (GBM).

Down-regulation of transcription factor OVOL2 contributes to epithelial-mesenchymal transition in a noninvasive type of trophoblast implantation to the maternal endometrium.

Rulan Bai et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(6), 3371-3384 (2018-02-03)

Embryo implantation into the uterine endometrium is required for pregnancy establishment in most mammals. By using global expression analysis, we investigated the molecules that are related to epithelial-mesenchymal transition (EMT) in noninvasive bovine trophoblasts and found that the transcription factor

MiR-18a-5p contributes to enhanced proliferation and migration of PASMCs via targeting Notch2 in pulmonary arterial hypertension.

Renying Miao et al.

Life sciences, 257, 117919-117919 (2020-06-26)

This study is undertaken to investigate the role and molecular mechanisms of miR-18a-5p in regulating pulmonary arterial hypertension (PAH) pathogenesis. Gene expression and protein levels were determined by qRT-PCR and western blot, respectively; Cell counting kti-8 and Transwell migration assays

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문서

MISSION^® esiRNA