추천 제품
![[(BENZHYDRYLOXY)(PHENYL)METHYL]BENZENE AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/848/247/6351af74-e74c-4949-a644-d112b75e7677/640/6351af74-e74c-4949-a644-d112b75e7677.png)
분석
≥98% (HPLC)
형태
solid
색상
white
solubility
DMSO: >10 mg/mL
H2O: insoluble
저장 온도
room temp
SMILES string
CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
InChI
1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
InChI key
MJJALKDDGIKVBE-UHFFFAOYSA-N
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일반 설명
Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.
애플리케이션
Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.
생화학적/생리학적 작용
Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.
특징 및 장점
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Daniel Aguilar et al.
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), 56(2), 36-40 (2009-06-17)
Allergic rhinitis is an inflammatory disease of the nasal mucosa, with common symptoms, which is essentially characterized by nasal itching, nasal congestion, sneezing, hyaline rhinorrhea and repetitive sneezing. The disease is very common, 15% of the population worldwide suffers it.
N V Tsiskarishvili et al.
Georgian medical news, (167)(167), 52-56 (2009-03-12)
The clinical efficacy of antihistaminic preparation "Kestine" (Ebastine) in combined treatment of 50 patients suffering from photo-allergic dermatosis (15 - solar urticaria, 20 - solar erythema and 15 - solar eczema) are evaluated. Kestine in dosage of 10 mg a
Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata.
Manabu Ohyama et al.
Journal of dermatological science, 58(2), 154-157 (2010-04-15)
Ji-Hong Shon et al.
Journal of clinical pharmacology, 50(2), 195-204 (2009-10-21)
The present study was performed to elucidate the effects of itraconazole and rifampin on the pharmacokinetics and pharmacodynamics of ebastine, a nonsedative H1 receptor antagonist. In a 3-way crossover sequential design with 2-week washouts, 10 healthy participants were pretreated with
Edward D Levin et al.
European journal of pharmacology, 650(1), 256-260 (2010-10-19)
Nicotine has been definitively shown to be critically involved in the neural bases of tobacco addiction. However, nicotine releases a wide variety of neurotransmitters. Nicotine-induced dopamine release has been shown to play a key role in facilitating nicotine self-administration. Other
문서
We offers many products related to histamine receptors for your research needs.
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