생물학적 소스
mouse
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
EEA1-C33, monoclonal
양식
buffered aqueous solution
분자량
antigen ~160 kDa
종 반응성
human, mouse, rat
농도
~1.0 mg/mL
기술
western blot: 2-4 μg/mL using whole extract of rat NRK or human HeLa cells
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... EEA1(8411)
mouse ... Eea1(216238)
rat ... Eea1(314764)
일반 설명
The gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol.
애플리케이션
Monoclonal Anti-EEA1 antibody produced in mouse is suitable for the following applications:
- Western blotting (at a concentration of 2-4μg/mL using whole extract of rat NRK or human HeLa cells)
- Immunofluorescence Analysis
- Immunocytochemistry
생화학적/생리학적 작용
Early Endosome Antigen 1 (EEA1) controls vesicle fusion during endocytosis. In neurons, it is involved in recycling of synaptic vesicles and neurotransmitter receptors. Patients with neurological deficits develop EEA1 autoantibodies. Mutation in EEA1 gene leads to susceptibility to diabetes in the Japanese population. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is essential for the localization and function of EEA1.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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