E1411

Proline Specific Endopeptidase from Flavobacterium sp.

lyophilized powder, ≥5.0 units/mg solid

• 동의어(들): EndoProC, Endoprolylpeptidase, Endoproteinase Pro-C, PEPase, Prolyl Endopeptidase
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: bacterial (Flavobacterium spp.)
• 형태: lyophilized powder
• 특이 활성도: ≥5.0 units/mg solid
• 분자량: ~78 kDa
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

애플리케이션

Proline specific endopeptidase is useful for the determination of amino acid sequences of peptides and proteins containing proline residues. Proline specific endopeptidases may be useful in cancer, neurology and diabetes research . Prolyl endopeptidase (PEP) may be used as a drug target for neuropsychiatric diseases such as stress disorder, depression, and schizophrenia .

생화학적/생리학적 작용

An endopeptidase is a proteolytic peptidase that breaks peptide bonds of nonterminal amino acids. Product E1411 is specific for proline (Pro). The Prolyl endopeptidase (PEP) mechanism is thought to be an induced fit mechanism, where the native enzyme exists in a conformationally flexible opened state but is changed to a closed state upon substrate binding .

단위 정의

One unit causes the formation of one micromole of p-nitroaniline per minute under specific pH and temperature conditions.

물리적 형태

White amorphous lyophilized powder

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable