D8440
15-Deoxy-Δ12,14-prostaglandin J2
≥95% (HPLC), 1 mg/mL in methyl acetate
동의어(들):
11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid, 15-Deoxy-Δ12,14-PGJ2
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C20H28O3
CAS Number:
Molecular Weight:
316.43
EC Number:
MDL number:
UNSPSC 코드:
12352211
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥95% (HPLC)
형태
liquid
농도
1 mg/mL in methyl acetate
배송 상태
wet ice
저장 온도
−20°C
SMILES string
CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
InChI
1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChI key
VHRUMKCAEVRUBK-GODQJPCRSA-N
일반 설명
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a prostaglandin J2 (PGJ2) metabolite and a naturally occurring derivative of prostaglandin D2. It is produced during inflammatory processes.
애플리케이션
15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
생화학적/생리학적 작용
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.
Selective agonist to PPARγ (peroxisome proliferator-activated receptors). Inhibits the proliferation of cancer cell lines that express PPARγ and cyclooxygenase-2 (COX-2).
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
표적 기관
Central nervous system
보충제 위험성
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
15.8 °F - closed cup
Flash Point (°C)
-9 °C - closed cup
개인 보호 장비
Eyeshields, Faceshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine.
C Thévenon et al.
Clinical chemistry, 47(4), 768-770 (2001-03-29)
15-Deoxy-$\Delta$ (12, 14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53
Ho TC, et al.
Test, 283(44), 30273-30288 (2008)
Gabriela Magenta et al.
BMC cancer, 8, 47-47 (2008-02-12)
Activation of peroxisome proliferator-activated receptors gamma (PPARgamma) induces diverse effects on cancer cells. The thiazolidinediones (TZDs), such as troglitazone and ciglitazone, are PPARgamma agonists exhibiting antitumor activities; however, the underlying mechanism remains inconclusive. Rosiglitazone (RGZ), a synthetic ligand of PPARgamma
15-Deoxy-Delta 12, 14-prostaglandin J2 inhibits multiple steps in the NF-kappa$B signaling pathway
Straus DS, et al.
Proceedings of the National Academy of Sciences, 97(9), 4844-4849 (2000)
Min Zhao et al.
Oncotarget, 7(40), 64690-64701 (2016-09-08)
Accumulating evidence suggests that loss of the renal tubular epithelial phenotype plays an important role in the pathogenesis of renal tubulointerstitial fibrosis. Systemic activation of peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to be protective against renal fibrosis, although
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