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D5446

Sigma-Aldrich

7,8-Dihydroxyflavone hydrate

≥98% (HPLC)

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크기 선택

10 MG
₩168,896
50 MG
₩682,994

₩168,896

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(1)

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보기 변경
10 MG
₩168,896
50 MG
₩682,994

About This Item

실험식(Hill 표기법):
C15H10O4 · xH2O
CAS Number:
38183-03-8
Molecular Weight:
254.24 (anhydrous basis)
EC Number:
253-812-4
MDL number:
MFCD00006836
UNSPSC 코드:
12352200
PubChem Substance ID:
329798806
NACRES:
NA.77

₩168,896

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

분석

≥98% (HPLC)

양식

solid

저장 조건

desiccated

solubility

DMSO: 24 mg/mL

저장 온도

room temp

SMILES string

Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3

InChI

1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChI key

COCYGNDCWFKTMF-UHFFFAOYSA-N

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애플리케이션

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice[1][2] and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).[3]

생화학적/생리학적 작용

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension.[4] 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.[5]
7,8-Dihydroxyflavone is a selective TrkB receptor agonist
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
037M4733V
026M4735V
045M4718V
025M4726V
114M4740V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem
Jang M, et al.
eLife, 8, e42156-e42156 (2019)
Xiaojuan Liu et al.
Molecules (Basel, Switzerland), 25(4) (2020-02-23)
O-methylation of flavonoids is an important modification reaction that occurs in plants. O-methylation contributes to the structural diversity of flavonoids, which have several biological and pharmacological functions. In this study, an O-methyltransferase gene (CrOMT2) was isolated from the fruit peel
Vasorelaxing and antihypertensive effects of 7, 8-dihydroxyflavone
Huai R
American Journal of Hypertension, 27(5), 750-760 (2013)
Maria N Schultz et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 346-354 (2020-08-21)
Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the maternal allele of the gene Ube3a The primary symptoms of Angelman syndrome are severe cognitive deficits, impaired motor functions, and speech disabilities. Analogous phenotypes have been detected
Natalie Groves et al.
Developmental neurobiology, 79(9-10), 868-879 (2019-12-31)
Brain-derived neurotrophic factor (BDNF) signaling plays a major role in the regulation of hippocampal neurogenesis in the adult brain. While the majority of studies suggest that this is due to its effect on the survival and differentiation of newborn neurons
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질문

  1. What are the recommended storage conditions for D5446 after reconstitution?

    1 답변

    1. Although there is no datasheet available for product D5446, there is information available for a product sharing the same CAS number from a different division. Below is the information found for product 506300 (7,8 Dihydroxyflavone):

      - Solubility: DMSO (100 mg/ml)
      - Storage: Protect from light, +2°C to +8°C
      - Do Not Freeze: Ok to freeze
      - Special Instructions: Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

      This information will also apply for product D5446. There are additional notes stating the product is packaged under inert gas. Therefore, if storing, it would be best to leave no air space in the storage container if possible. If that is not possible, it would be best to store under either dry nitrogen or argon.

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