D5321

D36 hydrate

≥98% (HPLC)

• 동의어(들): 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• 실험식(Hill 표기법): C₂₁H₂₄N₂O₂ · xH₂O
• CAS Number: 1228184-64-2
• Molecular Weight: 336.43 (anhydrous basis)
• MDL number: MFCD16875421
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329798803

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: DMSO: >10 mg/mL
• 주관자: GlaxoSmithKline
• 저장 온도: 2-8°C
• SMILES string: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
• InChI key: ZERKAKHVUQMJPW-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

특징 및 장점

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable