추천 제품
애플리케이션
Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice.
생화학적/생리학적 작용
Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.
Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only.
특징 및 장점
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
기타 정보
Isolated initially from Dendroaspis polylepis polylepis venom
제조 메모
Purified by a modification of the method of Schweitz.
재구성
Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1. 1 and 1.2 alpha subunits
Wang FC, et al.
European Journal of Biochemistry, 263(1), 222-229 (1999)
Cav1. 3 calcium channels are required for normal development of the auditory brainstem
Hirtz JJ, et al.
The Journal of Neuroscience, 31(22), 8280-8294 (2011)
Effects of voltage-gated K+ channel blockers in gefitinib-resistant H460 non-small cell lung cancer cells
Jeon WIL, et al.
Anticancer Research, 32(12), 5279-5284 (2012)
F C Wang et al.
European journal of biochemistry, 263(1), 222-229 (1999-08-03)
Dendrotoxin (DTX) homologues are powerful blockers of K+ channels that contain certain subfamily Kv1 (1.1-1.6) alpha- and beta-subunits, in (alpha)4(beta)4 stoichiometry. DTXk inhibits potently Kv1.1-containing channels only, whereas alphaDTX is less discriminating, but exhibits highest affinity for Kv1.2. Herein, the
Analog modulation of spike-evoked transmission in CA 3 circuits is determined by axonal K v1. 1 channels in a time-dependent manner
Bialowas A, et al.
The European Journal of Neuroscience, 41(3), 293-304 (2015)
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