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Merck
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주요 문서

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C7041

Sigma-Aldrich

McN-A-343

≥98% (TLC)

동의어(들):

(4-Hydroxy-2-butynyl)-1-trimethyl­ammonium-3-chloro­carbanilate chloride, 4-[N-(3-Chlorophenyl)carbamoyloxy]-2-­butynyl­trimethyl­ammonium chloride

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About This Item

실험식(Hill 표기법):
C14H18Cl2N2O2
CAS Number:
55-45-8
Molecular Weight:
317.21
MDL number:
MFCD00055068
UNSPSC 코드:
12352106
PubChem Substance ID:
24277827
NACRES:
NA.77

Quality Level

200

분석

≥98% (TLC)

양식

powder

색상

off-white

solubility

H2O: soluble
ethanol: soluble

SMILES string

[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1

InChI

1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H

InChI key

CXFZFEJJLNLOTA-UHFFFAOYSA-N

유전자 정보

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)
rat ... Chrm1(25229)

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생화학적/생리학적 작용

M1 muscarinic acetylcholine receptor agonist.

제조 메모

Solutions may be stored for several days at 4 °C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000105240
0000105241
13090705
074M4003V
107M4013V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리 방문

Frederick J Mitchelson
Pharmacology & therapeutics, 135(2), 216-245 (2012-05-31)
The unusual pharmacology of McN-A-343 was first described by Roszowski in 1961. The agonist appeared to be a selective stimulant of muscarinic receptors in sympathetic ganglia, now known to be the muscarinic M₁ receptor subtype. However, subsequent research demonstrated that
Lauren T May et al.
Molecular pharmacology, 72(2), 463-476 (2007-05-26)
The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions of allosteric agonists, as opposed to modulators
Dedmer Schaafsma et al.
British journal of pharmacology, 147(7), 737-743 (2006-01-25)
In airway smooth muscle (ASM), full and partial muscarinic receptor agonists have been described to have large differences in their ability to induce signal transduction, including Ca2+-mobilization. Despite these differences, partial agonists are capable of inducing a submaximal to maximal
Laura Oliveira et al.
Neuro-Signals, 14(5), 262-272 (2005-11-23)
At the rat motor endplate, pre-synaptic facilitatory adenosine A2A and muscarinic M1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M1 facilitation of [3H]ACh release was partially recovered when CGS21680C
Hinako Suga et al.
Molecular pharmacology, 78(4), 745-755 (2010-07-21)
Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this
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