C6607

Caspase 10 human

>90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 8,000 units/mg protein (Bradford)

• 동의어(들): Flice2, Mch4
• MDL number: MFCD03456342
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 분석: >90% (SDS-PAGE)
• 형태: lyophilized powder
• 특이 활성도: 8,000 units/mg protein (Bradford)
• 분자량: ~30 kDa
• solubility: PBS: soluble
• UniProt 수납 번호: Q92851
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CASP10(843)

설명

생화학적/생리학적 작용

Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner.

단위 정의

One unit will hydrolyze 1 nmol of the caspase substrate IETD-pNA to IETD and p-nitroaniline per hour at pH 7.2 at 37 °C.

물리적 형태

Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable