모든 사진(1)
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1 G
₩253,446
About This Item
Linear Formula:
C15H16N7O5S3Na
CAS Number:
Molecular Weight:
493.52
MDL number:
UNSPSC 코드:
51282205
PubChem Substance ID:
NACRES:
NA.85
추천 제품
양식
powder
유통기한
limited shelf life, expiry date on the label
solubility
H2O: 50 mg/mL
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
동작 모드
cell wall synthesis | interferes
저장 온도
2-8°C
SMILES string
[Na+].[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@]2(NC(=O)CSCC#N)OC)C([O-])=O
InChI
1S/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13-,15+;/m1./s1
InChI key
BITQGIOJQWZUPL-PBCQUBLHSA-M
일반 설명
Chemical structure: ß-lactam
애플리케이션
Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding proteins (PDPs) other than PBP2 on bacterial cell wall mucopeptide synthesis. Cefmetazole is used to study protein mediated transport of antibiotics.[1]
생화학적/생리학적 작용
Cefmetazole disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cefmetazole mimics the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan. It is effective against both Gram-positive and Gram-negative bacteria.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
기타 정보
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic Handle and store under inert gas.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Shin Fujita et al.
Archives of surgery (Chicago, Ill. : 1960), 142(7), 657-661 (2007-07-20)
Use of prophylactic antibiotics in elective colorectal surgery is essential. Although single-dose prophylactic antibiotics are recommended, the efficacy of single-dose cephalosporin without metronidazole and oral antibiotics is not fully proven. We conducted a multicenter, randomized trial of a single dose
Hirotoshi Okumura et al.
Toxicological sciences : an official journal of the Society of Toxicology, 97(2), 533-538 (2007-03-08)
The liver of a chimeric urokinase-type plasminogen activator (uPA)(+/+)/severe combined immunodeficient (SCID) mouse line recently established in Japan could be replaced by more than 80% with human hepatocytes. We previously reported that the chimeric mice with humanized liver could be
Junzo Shimizu et al.
Surgery today, 40(10), 954-957 (2010-09-28)
Postoperative antimicrobial therapy is generally administered as standard prophylaxis against postoperative infection, despite a lack of sufficient evidence for its usefulness. This study was a phase II study to evaluate the necessity of postoperative antibiotic prophylaxis in patients undergoing a
Minako Kobayashi et al.
Surgery today, 40(4), 326-333 (2010-03-27)
To evaluate the effectiveness of our surgical site infection (SSI) preventive strategies for rectal cancer patients. We compared the incidences and risk factors for SSI before (1990-1999) and after the implementation of our SSI prevention policies (2002-2006). A total of
Yukio Kato et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 1088-1096 (2008-03-15)
In the present study, we attempted to identify the membrane permeation process(es) primarily involved in the molecular-weight-dependent biliary excretion of beta-lactam antibiotics. A search of the literature indicated that the molecular weight threshold operates mainly in the transport process across
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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