C2538

Carboplatin

• 동의어(들): cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
• Linear Formula: [C₄H₆(CO₂)₂]Pt(NH₃)₂
• CAS Number: 41575-94-4
• Molecular Weight: 371.25
• EC Number: 255-446-0
• MDL number: MFCD00070464
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278303
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 100
• 항생제 활성 스펙트럼: neoplastics
• 주관자: Bristol-Myers Squibb
• SMILES string: N.N.O=C1O[Pt]OC(=O)C12CCC2
• InChI: 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
• InChI key: OLESAACUTLOWQZ-UHFFFAOYSA-L

설명

일반 설명

Carboplatin is used to treat testicular, ovarian and breast cancer.[1]

애플리케이션

Carboplatin has been used:

• in chemotherapy-induced thrombocytopenia mouse model and treatment[2]
• to induce cell death in a large subset of colorectal cancer cells[3]
• in the evaluation of cell proliferation and chemosensitivity[4]
• as a positive control for suppressed cell growth[5]

생화학적/생리학적 작용

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302 + H312 + H332,H317,H334,H340,H360
• 예방조치 성명서: P202 - P261 - P280 - P301 + P312 - P302 + P352 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges