추천 제품
분석
≥94% (HPLC)
Quality Level
양식
solid
저장 온도
−20°C
SMILES string
NC(=O)c1cc(N2CC2)c(cc1[N+]([O-])=O)[N+]([O-])=O
InChI
1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)
InChI key
WOCXQMCIOTUMJV-UHFFFAOYSA-N
애플리케이션
CB 1954 has been used in drug-induced ablation studies.
생화학적/생리학적 작용
CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase 2.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Mayumi Hirakawa et al.
Scientific reports, 8(1), 11095-11095 (2018-07-25)
The numbers of thymic epithelial cells (TECs) and thymocytes steadily increase during embryogenesis. To examine this dynamic, we generated several TEC-specific transgenic mouse lines, which express fluorescent proteins in the nucleus, the cytosol and in the membranes under the control
Karine Reybier et al.
Free radical research, 45(10), 1184-1195 (2011-07-19)
NRH:quinone oxidoreductase 2 (QR2) is a cytosolic enzyme that catalyzes the reduction of quinones, such as menadione and co-enzymes Q. With the aim of understanding better the mechanisms of action of QR2, we approached this enzyme catalysis via electron paramagnetic
Jolanda J de Poorter et al.
Human gene therapy, 19(10), 1029-1038 (2008-10-30)
Revision surgery for loosened hip prostheses is a heavy burden for elderly patients with comorbidity. As an alternative to surgery we performed a study to stabilize the prosthesis by percutaneous cement injection after removing inflammatory tissue with an intraarticular virus-directed
Guillaume Macary et al.
Virchows Archiv : an international journal of pathology, 456(3), 325-337 (2009-10-07)
The present work identifies a new mouse model of inductible acute glomerular injury leading to focal segmental glomerulonephritis. We take advantage of the suicide gene/prodrug nitroreductase/CB1954 combination, in which nitroreductase converts CB1954, a monofunctional alkylating agent, into its toxic form.
Prashant Patel et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(7), 1292-1299 (2009-04-16)
We report a phase I/II clinical trial in prostate cancer (PCa) using direct intraprostatic injection of a replication defective adenovirus vector (CTL102) encoding bacterial nitroreductase (NTR) in conjunction with systemic prodrug CB1954. One group of patients with localized PCa scheduled
문서
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.