추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
TD.1, monoclonal
양식
buffered aqueous solution
분자량
antigen 180-192 kDa
종 반응성
rat, human, bovine, mouse
농도
~2 mg/mL
기술
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 2-4 μg/mL using whole extract of cultured rat adrenal pheochromocytoma PC-12 cells.
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CLTC(1213)
mouse ... Cltc(67300)
rat ... Cltc(54241)
일반 설명
Clathrin, a three legged structure refer as triskelion is the main component of polygonal network and forms the coat of coated vesicles and coated pits. Clathrin-coated vesicles accounts for receptor mediated endocytosis at the plasma membrane and also play a crucial role in hormone secretion and mechanism of action. Monoclonal Anti-Clathrin Heavy Chain antibody can be used to study the mechanism of clathrin mediated membrane trafficking during hormonal stimulation and protein phosphorylation. Mouse monoclonal anti-clathrin heavy chain antibodies are react specifically with clathrin heavy chain CHC17 but do not cross react with muscle isoform CHC22.
면역원
globular N-terminal domain of bovine clathrin heavy chain.
애플리케이션
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Clathrin Heavy Chain antibody can be used in immunoblotting. It can also be used in western blotting to characterize clathrin heavy chain levels
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
David Rhainds et al.
Journal of cell science, 117(Pt 15), 3095-3105 (2004-07-01)
The scavenger receptor class B, type I (SR-BI) mediates cholesteryl esters (CE) selective uptake from low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. In a number of tissues expressing caveolin, SR-BI is localized in caveolae. We show using detergent-free
P Narducci et al.
European journal of histochemistry : EJH, 54(1), e6-e6 (2010-04-01)
Bone is continuously repaired and remodelled through well-coordinated activity of osteoblasts that form new bone and osteoclasts, which resorb it. Osteoblasts synthesize and secrete two key molecules that are important for osteoclast differentiation, namely the ligand for the receptor of
I S Näthke et al.
Cell, 68(5), 899-910 (1992-03-06)
The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized.
Guillaume A Castillon et al.
Traffic (Copenhagen, Denmark), 19(3), 215-228 (2018-01-21)
Recently, studies in animal models demonstrate potential roles for clathrin and AP1 in apical protein sorting in epithelial tissue. However, the precise functions of these proteins in apical protein transport remain unclear. Here, we reveal mistargeting of endogenous glycosyl phosphatidyl
Chunjiang Yu et al.
Molecular neurodegeneration, 5, 19-19 (2010-05-19)
One pathological hallmark of Alzheimer's disease (AD) is amyloid plaques, composed primarily of amyloid-beta peptide (Abeta). Over-production or diminished clearance of the 42 amino acid form of Abeta (Abeta42) in the brain leads to accumulation of soluble Abeta and plaque
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