B6060

BVT.948

≥98% (HPLC), solid

• 동의어(들): 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• 실험식(Hill 표기법): C₁₄H₁₁NO₃
• CAS 번호: 39674-97-0
• Molecular Weight: 241.24
• NACRES: NA.77
• PubChem Substance ID: 24724422
• UNSPSC Code: 12352200
• MDL number: MFCD00616487
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, protect from light, under inert gas

속성

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light, under inert gas
• color: red
• solubility: DMSO: 18 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

설명

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

안전성 정보

• 픽토그램: GHS07
• 경고어: Warning
• 위험 코드: H317
• 주의 사항: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• 저장 등급: 11 - Combustible Solids
• 무슨 일이 일어나고 있는 걸까?: WGK 3
• 인화점 (F): Not applicable
• 인화점 (°C): Not applicable
• 개인 보호 장비(PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves