B5437

Bendamustine hydrochloride hydrate

≥98% (HPLC)

• 동의어(들): 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride, Treanda
• 실험식(Hill 표기법): C₁₆H₂₁Cl₂N₃O₂·HCl · xH₂O
• CAS 번호: 1374784-02-7
• Molecular Weight: 394.72 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329773260
• UNSPSC Code: 12352200
• MDL number: MFCD16879055
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

속성

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: off-white
• solubility: H₂O: >30 mg/mL
• originator: Teva
• storage temp.: room temp
• SMILES string: O.Cl.Cn1c(CCCC(O)=O)nc2cc(ccc12)N(CCCl)CCCl
• InChI: 1S/C16H21Cl2N3O2.ClH.H2O/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H;1H2
• InChI key: TWBJYCLUHINEDN-UHFFFAOYSA-N

설명

General description

Bendamustine comprises 2-chloroethylamine alkylating group, a butyric acid side chain and a benzimidazole ring in its structure and is a nitrogen mustard. It is catabolized in the liver by the enzyme cytochrome P450 1A2 into γ hydroxyl-bendamustine and N-desmethyl-bendamustine.

Application

Bendamustine hydrochloride hydrate has been used as:

• a chemotherapy agent for chronic lymphocytic leukemia (CLL) samples to monitor spliced and unspliced gene expression
• an inhibitor to E3 ubiquitin-protein ligase RNF3 (HOIP) in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) assay
• a cytotoxic chemotherapeutic drug in high-throughput screening to test interaction with BAY87-2243

Biochem/physiol Actions

Bendamustine is a therapeutic agent employed in treating lymphomas and chronic lymphocytic leukemia. It may be useful in central nervous system (CNS) malignancies treatment regimen due to its penetration capacity into brain tissue. Bendamustine is a promising candidate for non-Hodgkin lymphoma and Hodgkin lymphoma therapies.

Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. Bendamustine activates DNA-damage stress response and apoptosis; inhibits mitotic checkpoints; and induces mitotic catastrophe.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06,GHS08
• 경고어: Danger
• 위험 코드: H301,H341,H351,H361fd
• 주의 사항: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 2
• 저장 등급: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 무슨 일이 일어나고 있는 걸까?: WGK 3
• 인화점 (F): Not applicable
• 인화점 (°C): Not applicable
• 개인 보호 장비(PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves