B3436
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide
≥98% (HPLC), solid
동의어(들):
C2-8
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크기 선택
5 MG
₩276,486
25 MG
₩991,655
모든 사진(1)
크기 선택
보기 변경
5 MG
₩276,486
25 MG
₩991,655
About This Item
실험식(Hill 표기법):
C19H14Br2N2O3S
CAS Number:
Molecular Weight:
510.20
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
![4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester ≥98.0% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/120/235/500b5276-3ce2-43b7-9588-3883f13d4ff7/640/500b5276-3ce2-43b7-9588-3883f13d4ff7.png)
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
off-white
solubility
DMSO: ~20 mg/mL
H2O: insoluble
저장 온도
2-8°C
SMILES string
Brc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1
InChI
1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)
InChI key
SJJKUNDBFWUAQB-UHFFFAOYSA-N
생화학적/생리학적 작용
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl] benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin).
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Aquatic Chronic 4 - Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
가장 최신 버전 중 하나를 선택하세요:
Xiaoqian Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(3), 892-897 (2005-01-12)
Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene products. In polyQ diseases, the pathology and death of affected neurons are associated with the accumulation of mutant proteins in insoluble aggregates.
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