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Merck
모든 사진(1)

문서

B2805

Sigma-Aldrich

Bone Morphogenetic Protein 6 human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

동의어(들):

BMP-6

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

Quality Level

재조합

expressed in NSO cells

분석

>95% (SDS-PAGE)

형태

lyophilized powder

효능

0.05-0.15 μg/mL ED50

분자량

30–38 kDa

포장

pkg of 20 μg

저장 조건

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

기술

cell culture | mammalian: suitable

불순물

endotoxin, tested

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... BMP6(654)

생화학적/생리학적 작용

Cellular responses to BMP-6 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Mature human and murine BMP-6 demonstrates 96% homology.

물리적 형태

Lyophilized from 200 ul 0.2 μm filtered solution in 40% acetonitrile, 0.1% trifluoroacetic acid containing 50ug bovine serum albumin per 1 ug as a carrier protein.

분석 메모

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Bone morphogenetic proteins and their receptors: potential functions in the brain.
Ebendal, T., et al
The Journal of Neuroscience, 51, 139-146 (1998)
Stephanie Arndt et al.
Gut, 64(6), 973-981 (2014-07-12)
Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this
Christine E McLaren et al.
Hepatology (Baltimore, Md.), 62(2), 429-439 (2015-01-22)
To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron
Hiroshi Kawabata et al.
Experimental hematology, 43(5), 404-413 (2015-01-31)
Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation. To identify molecules that modulate hepcidin expression, we developed a bioassay system for hepcidin gene
Zhu Xishan et al.
Journal of experimental & clinical cancer research : CR, 30, 47-47 (2011-05-04)
Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not

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