B0189

Casticin

from Vitex trifolia, ≥98% (HPLC)

• 동의어(들): Casticine, Quercetagetin 3,6,7,4′-tetramethyl ether, Vitexicarpin
• 실험식(Hill 표기법): C₁₉H₁₈O₈
• CAS Number: 479-91-4
• Molecular Weight: 374.34
• UNSPSC 코드: 12352200
• NACRES: NA.25

속성

• 생물학적 소스: Vitex trifolia
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: ethanol: 1 mg/mL, clear, colorless to light yellow
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: 2-8°C
• InChI: 1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
• InChI key: PJQLSMYMOKWUJG-UHFFFAOYSA-N

설명

일반 설명

Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb.[1] It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.[2]

애플리케이션

Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.

생화학적/생리학적 작용

Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.[2]

Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable