A9477

Aldosterone

≥95% (HPLC), powder

• 동의어(들): 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X
• 실험식(Hill 표기법): C₂₁H₂₈O₅
• CAS Number: 52-39-1
• Molecular Weight: 360.44
• Beilstein: 3224996
• EC Number: 200-139-9
• MDL number: MFCD00051136
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24891458
• NACRES: NA.77

속성

• product name: Aldosterone, ≥95% (HPLC)
• 생물학적 소스: synthetic (organic)
• 무균: non-sterile
• 분석: ≥95% (HPLC)
• 형태: powder
• 기술: cell culture | mammalian: suitable
• solubility: chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O
• InChI: 1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
• InChI key: PQSUYGKTWSAVDQ-ZVIOFETBSA-N
• 유전자 정보: human ... SERPINA6(866) ; rat ... Ar(24208) , Nr3c2(25672)

설명

일반 설명

Aldosterone plays a significant role in the multi-factorial regulation of salt, potassium, blood pressure, and acid-base balance. It is also involved in maternal volume expansion during fetal development to support fetal perfusion and may contribute to the increased expression of placental growth factors. While its primary activity is associated with the kidney, aldosterone can also interact with mineralocorticoid receptors in other tissues such as the gastrointestinal tract, respiratory epithelium, myocardium, and vascular smooth muscle. Aldosterone antagonists or mineralocorticoid receptor antagonists (MRAs) can be beneficial for patients with various clinical conditions, including primary aldosteronism (PA), primary and resistant hypertension, heart failure (HF), and chronic kidney disease (CKD).

애플리케이션

Aldosterone has been used:

• as a RPMI-1640 medium supplement for podocyte culture to test its pathogenicity in obesity-related glomerulopathy (ORG)
• in combination with salt to induce renal injury in mice
• to stimulate primary liver sinusoidal endothelial cells (LSECs) and in the generation of hyperaldosteronism model in mice

The d-isomer of aldosterone is considered to be the biologically active isomer.

생화학적/생리학적 작용

Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex. It induces urinary excretion of K⁺ and renal reabsorption of Na⁺. It is produced from adrenocorticotropic hormone (ACTH) and is essential for maintaining sodium homeostasis in the distal tubules. Aldosterone binds to the mineralocorticoid receptor and may modulate vascular system and induce kidney damage. It contributes to the progression of chronic kidney disease(CKD). Aldosterone is part of the renin-angiotensin-aldosterone system (RAAS).

기타 정보

Exists as an equilibrium mixture of the aldehyde and the hemiacetal.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)