A7275

L-2-Aminoadipic acid

≥98% (TLC), powder, glutamine synthetase inhibitor

• 동의어(들): (S)-2-Aminohexanedioic acid, L-Homoglutamic acid, Aad
• Linear Formula: HO₂C(CH₂)₃CH(NH₂)CO₂H
• CAS Number: 1118-90-7
• Molecular Weight: 161.16
• Beilstein: 1724348
• MDL number: MFCD00002636
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24278234
• NACRES: NA.32

속성

• 제품명: L-2-Aminoadipic acid, ≥98% (TLC)
• 분석: ≥98% (TLC)
• 양식: powder
• mp: 203-205 °C (dec.) (lit.)
• SMILES string: N[C@@H](CCCC(O)=O)C(O)=O
• InChI: 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
• InChI key: OYIFNHCXNCRBQI-BYPYZUCNSA-N
• 유전자 정보: human ... GLUL(2752) , LGSN(51557) ; rat ... Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418) , Grm6(24419)

설명

일반 설명

L-2-Aminoadipic acid/α-aminoadipate is a gliotoxin and is a structural analog of glutamine.[1] It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways.[2]

애플리케이션

L-2-Aminoadipic acid has been used as a gliotoxin specific for astrocytes in rat.[3][4] It has also been as an internal standard in the amino acid analysis from fermented food sample.[5]

생화학적/생리학적 작용

L-2-Aminoadipic acid inhibits glutamine synthetase and γ-glutamylcysteine synthetase.[1] It modulates glucose metabolism and is present in higher levels in diabetic patients.[6] L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes.[2]

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)