모든 사진(1)
About This Item
실험식(Hill 표기법):
C17H15N7Na2O8S4
CAS Number:
Molecular Weight:
619.58
UNSPSC 코드:
51282206
NACRES:
NA.85
추천 제품
양식
powder
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
동작 모드
cell wall synthesis | interferes
저장 온도
2-8°C
InChI
1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1
InChI key
ZQQALMSFFARWPK-GLHLDKNHSA-L
생화학적/생리학적 작용
Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.[1]
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.[2]
기타 정보
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Paul Suding et al.
Archives of surgery (Chicago, Ill. : 1960), 143(9), 907-911 (2008-09-17)
Anastomotic leaks following elective colorectal resections increase morbidity, mortality, and the need for additional interventions. An accurate understanding of risk factors would potentially reduce anastomotic leaks and/or allow appropriate selection of patients for diverting stomas. Prospective review of patient and
Wookeun Lee et al.
The Korean journal of laboratory medicine, 29(5), 448-454 (2009-11-07)
Plasmid-mediated AmpC beta-lactamases (PABLs) have been detected in the strains of Escherichia coli, Klebsiella spp., Proteus mirabilis, and Salmonella spp. PABLs may be difficult to detect and might interfere in the therapeutic and infection-control processes. Although several PABL-detection methods based
Failure to administer cefotan: was standing order ambiguous? Tucker v. Women's Care Physicians of Louisville, CA-001929-mr(6/18/2010)-KY.
Nursing law's Regan report, 51(3), 2-2 (2010-11-26)
Susan T Johnson et al.
Transfusion, 47(4), 697-702 (2007-03-27)
Drug-induced immune hemolytic anemia (DIIHA) is an uncommon finding characterized by a sudden decrease in hemoglobin after treatment with the putative drug. The full range of drugs causing DIIHA and the initial serologic presentation are not fully appreciated. This work
Ellie J C Goldstein et al.
Surgical infections, 10(2), 111-118 (2009-02-20)
A randomized study comparing single-dose cefotetan and ertapenem prophylaxis for elective colorectal surgery in 1,002 patients found ertapenem to be significantly more effective (p < 0.001). Failures of prophylaxis were thought to involve organisms resistant to both antimicrobial agents, isolated
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