추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
203-217/6, monoclonal
양식
buffered aqueous solution
분자량
antigen 47-51 kDa
종 반응성
mouse, canine, rat, chicken, bovine, human, rabbit
기술
immunocytochemistry: suitable using methanol or 1% paraformaldehyde/0.1% glutaraldehyde
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using whole cell extract of culture mouse connective tissue (A9) cells.
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ANXA7(310)
mouse ... Anxa7(11750)
rat ... Anxa7(155423)
일반 설명
Annexin VII (synexin) is a membrane binding protein that localizes in the nucleus and cytosol. In humans and mice, Annexin VII is encoded by a single gene that has alternatively spliced cassette exons. As a result, two isoforms of molecular mass of 47kDa and 51kDa are expressed. These isoforms differ in their N-terminal region and also have distinct tissue-specific expression patterns.
Anti-Annexin VII antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 203-217/6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant mouse Annexin VII. The human annexin VII (ANXA7) is located on chromosome 10q21.
특이성
Mouse monoclonal anti-annexin VII antibody reacts with human, bovine, rabbit, dog, rat, mouse, and chicken Annexin VII.
면역원
recombinant mouse annexin VII.
애플리케이션
Anti-Annexin VII antibody, Mouse monoclonal has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
생화학적/생리학적 작용
Antibodies reacting specifically with Annexin VII serve as an essential tool for the detection of this molecule in various cells. The human annexin VII (ANXA7) possesses a tumor suppressor role in prostate cancer. Hence it can be used an important biomarker along with syndecan-1 to predict the survival rates in prostate cancer patients.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression
Leighton X, et al.
Testing, 13(10), e0205837-e0205837 (2018)
Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model
Jin Y, et al.
BMC Cancer, 13(1), 522-522 (2013)
ShuYan Liu et al.
Cancer letters, 416, 11-23 (2017-12-17)
Annexin A7 (ANXA7) is a suppressor of tumorigenesis and metastasis in prostate cancer. Activated ANXA7 GTPase promotes prostate cancer cell apoptosis. However, the role and underlying mechanism of ANXA7 GTPase in prostate cancer metastasis have not been established. RKIP is
C S Clemen et al.
Journal of muscle research and cell motility, 20(7), 669-679 (2000-02-15)
Annexin VII exists in a 47 kDa and a 51 kDa isoform with the 51 kDa protein being the only isoform present in skeletal muscle. Expression of the 51 kDa isoform during myogenesis and localization was studied in cells after
Yanling Jin et al.
BMC cancer, 13, 522-522 (2013-11-06)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in China. This study investigated the effects of Annexin A7 (ANXA7) on the inhibition of HCC lymph node metastasis in a mouse model. The stable knockup and knockdown
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